Releases

Advances and Perspectives in the Treatment of T-PLL

Authors: Till Braun, Jana von Jan, Linus Wahnschaffe, Marco Herling
Journal: Current Hematologic Malignancy Reports, 7 February 2020 (10.1007/s11899-020-00566-5)
Advances in Covalent Inhibitors for Kinases

Authors: Abdeldayem A., Raouf Y.S., Constantinescu S., Moriggl R., Gunning P.T.
Journal: Chem. Soc. Rev. 2020
JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.

Authors: Linus Wahnschaffe, Till Braun, Sanna Timonen, Anil K. Giri, Alexandra Schrader, Prerana Wagle, Henrikki Almusa, Patricia Johansson, Dorine Bellanger, Cristina López, Claudia Haferlach, Marc-Henri Stern, Jan Dürig, Reiner Siebert, Satu Mustjoki, Tero Aittokallio and Marco Herling
Journal: Cancers 11(12), 1833. Published: 21 November 2019 (https://doi.org/10.3390/cancers11121833)
Optimization of a High-Throughput Fluorescence Polarization Assay for STAT5B DNA Binding Domain-Targeting Inhibitors

Authors: Manaswiyoungkul P., Erdogan F., Olaoye O.O., de Araujo E.D., Gunning P.T
Journal: J. Bio. Pharm. Anal(https://doi.org/10.1016/j.jpba.2020.113182)
Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers

Authors: Marie Brachet-Botineau, Marion Polomski, Heidi A. Neubauer, Ludovic Juen, Damien Hédou, Marie-Claude Viaud-Massuard, Gildas Prié and Fabrice Gouilleux.
Journal: Cancers (Basel), 12(1): pii: E240. Published 18 January, 2020. (https://doi.org/10.3390/cancers12010240)
The Stromal Microenvironment Provides An Escape Route From FLT3 Inhibitors Through The GAS6-AXL-STAT5 Axis

Authors: Anna Orlova, Heidi A. Neubauer, Richard Moriggl
Journal: Haematologica October 2019 104: 1907-1909 (https://doi.org/10.3324/haematol.2019.225862)
SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy

Authors: Aleksandr Ianevski, Sanna Timonen, Alexander Kononov, Tero Aittokallio, Anil K. Giri.
Journal: PLoS Comput Biol. 16(2):e10076. February 3, 2020 (https://doi.org/10.1371/journal.pcbi.1007604)
Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Authors: Elvin D. de Araujo, Anna Orlova, Heidi A. Neubauer, Dávid Bajusz, Hyuk-Soo Seo, Sirano Dhe-Paganon, György M. Keseru, Richard Moriggl and Patrick T. Gunning
Journal: Cancers (Basel), 11(11): pii: E1757. Published 8 November, 2019. (https://doi.org/10.3390/cancers11111757)
STAT3 and STAT5 Activation in Solid Cancers

Authors: Sebastian Igelmann, Heidi A. Neubauer and Gerardo Ferbeyre
Journal: Cancers (Basel), 11(10): pii: E1428. Published 25 September 2019. (https://doi.org/10.3390/cancers11101428)
Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

Authors: S. Pützer, L. Varghese, J. von Jan, T. Braun, A. K. Giri, P. Mayer, N. Riet, S. Timonen, S. Oberbeck, H. Kuusanmäki, S. Mustjoki, M.-H. Stern, T. Aittokallio, S. Newrzela, A. Schrader & M. Herling
Journal: Leukemia. 25 February 2020 (https://doi.org/10.1038/s41375-020-0772-6)
Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia

Authors: Paurnima Patil, Agata Cieslak, Stephan H. Bernhart, Umut H. Toprak, Rabea Wagener, Cristina López, Laura Wiehle, Susanne Bens, Janine Altmüller, Marek Franitza, Ingrid Scholz, Sandrine Jayne, Matthew J. Ahearne, Annika Scheffold, Billy M. C. Jebaraj, Christof Schneider, Dolors Costa, Till Braun, Alexandra Schrader, Elias Campo, Martin J. S. Dyer, Peter Nürnberg, Jan Dürig, Patricia Johansson, Sebastian Böttcher, Matthias Schlesner, Marco Herling, Stephan Stilgenbauer, Elizabeth Macintyre, Reiner Siebert
Journal: Genes Chromosomes Cancer, 29 October 2020, 59:261–267 (http:// https://doi.org/10.1002/gcc.22821)
Prediction of drug combination effects with a minimal set of experiments

Authors: Aleksandr Ianevski, Anil K. Giri, Prson Gautam, Alexander Kononov, Swapnil Potdar, Jani Saarela, Krister Wennerberg & Tero Aittokallio 
Journal: Nature Machine Intelligence volume 1, pages568–577(2019) (https://doi.org/10.1038/s42256-019-0122-4)